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News / 21 APRIL 2016

Ethiopathogenetic meaning of varicocele in development of men infertility

On March 30, 2016 ôEthiopathogenetic meaning of varicocele in development of men infertilityö seminar was held in Minsk which was attended by Belarusian urologists and andrologists.

Dmitry Nitkin, candidate of medical sciences, associate professor, head of nephrology and urology department of Belarus Medical Academy of Post-Graduate Education in his speech actualized prevalence of this pathology and problems related to it: according to current data around 15ľ20% of male adult population suffers from varicocele, whereas for men with primary infertility varicocele prevalence rate is around 40%, with secondary infertility up to 70%. In Belarus they use surgery and other invasive types of treatment but micronutrient therapy is an additional subfertility or infertility treatment option for patients with varicocele. This is stipulated by pathophysiological and therapeutic aspects of damage to sperm cells membrane by oxidative stress (unbalanced quantity of active forms of oxygen and potency of antioxidants). Good results of inflammation reduction and oxidative stress for men with varicocele can be achieved by micronutrients intake (vitamin ┼, glutathione and coenzyme Q10). They help improve the surrounding environment of the sperm cells. L-carnitine is vital for transport of fatty acids. For the time being, therapeutic use for varicocele of such micronutrients as zinc, selenium, folic acid and others have not been studied enough, but their intake in combination with antioxidants results in significant improvement of reproductive potential in men.

In the course of the seminar specialists were familiarized with PROfertil clinical trials (Lenus Pharma, Austria). In this trial at the Center of Childbirth of International medical clinic, Vienna, Austria, after excluding patients with infections, aspermia and hormonal disorders, 55 men (age 18-43, average age Ś 32 years old) with subclinical varicocele and infertility during at least 2 years (on an average of 2,7 years), as well as with two abnormal spermograms (done within an interval of at least on month) took part. Patients were administered a combination of micronutrients (PROfertil«): L-carnitin, L-arginin, vitamin ┼, folic acid, zinc, selenium, glutathione and coenzyme Q10 within three months. Sperm quality test demonstrated improvement of all parameters (ejaculate volume, sperm concentration, number of sperm cells with normal morphology and progressive mobility) which led to pregnancies in 41,18 % of cases.



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